Diets the fact that promote rapid weight-loss are not only detrimental to a person's health and fitness, they're also damaging weight loss. The band is scheduled around the upper most section of the stomach, dividing the stomach in a small upper portion and then a larger lower fraction. The best food items are ones it is easy to enjoy without sensing guilty. Reduction in weight is often brought out by way of actually burning the fat as well as by making you actually lose water fat and muscle excess fat (muscle is definitely 85% water). This is the stage where green tea differs from regular green teas and coffee, both of that show some attributes of green tea herb like increased intellectual alertness and rapidly metabolism, but, none can duplicate the herbal essence of green tea leaf.
For illustration, because 3, 500 calories means about one hammer or half some sort of kilogram of body fat, cutting 500 calories in your diet each working day would result in several one pound seven days. A forty 5 year old performing click here similar exercise would truly burn fewer calorie consumption than someone twenty years younger. It has nutrition-empty calories and forces you to gain fat. It is very best way to cut all your current undesirable fats. Work with your health care provider on a plan to lose weight for you.
First of the, it is essential to understand that this revolutionary slimming product, as termed through many, is actually their tea in its purest and a lot of unprocessed form. If a eating program states that you might want not work released, you might possibly seek for a different option. Well, what could be more advanced than losing weight in addition to looking good swiftly? With 32% unwanted weight, a 260 pounder possesses 83. 2 pounds of unwanted fat and 176. 8 pounds in lean mass. Before you go to find the good rapid weight-loss tricks, be sure that the goals are clear & mind is fixed to help you implement them.
The best advice you might EVER get is to pay attention to losing fat, not losing unwanted weight. This means that you'll encounter no wrinkles for your face and hands which can make you look a lot of younger than your real age. Degree of effectiveness depend in person to an additional but most whom take prescription weight-loss products lose pertaining to 5% to 10% of their weight. And, as Diet Daily life Tips suggests, the grazing having style is hard to look after. As long when losing fat not to mention losing those added inches week subsequent to week till an individual reach your best shape, you are on target for permanent weight-loss.
Lets have to deal with it, your weight and appearance might be a touchy, emotional subject. The excess excess calories we eat will be stored as abnormal fat and tend to be usually found with places like bellies, thighs, hips, upper arms, and the spine and neck. The key is to buy a diet plan in which stresses healthy dietary habits instead of indicating a person must only eat a definite food group or even cut calories in order to dangerous levels to be able to lose the excess fat. Learning what it will require to be nutritious and living from these principles eighty percent of that time period will keep ones healthy weight.
Think pertaining to your goal along with think bigger about your attempts. Taking control from your mind means taking control of the eating and physical exercise habits. Balancing on a left foot, bend your eventually left knee and slowly decrease body until a right heel lightly touches the bottom. Don't settle to get a "one size fits all" way of weight loss.
With the Saving Trust quarrelling that micro generated energy like that gathered from sun power panels could provide 30% to 40% within the UK's electricity by the centre of the century it's an excellent time to see what the whole set of fuss is in relation to. Next, you will.must find somewhere that is certainly large and thoroughly clean, where there's a designated surface to place the parts with, large enough to support the frame. Therefore solar panels really don't usually lose their particular value while stashed away on shelves (beyond sunlight)... unless a completely new photovoltaic technology emerges to exchange them. Getting started together with the initial set up would be the most difficult section, because from furthermore there on out, it's easy to settle back and enjoy less expensive energy. When using a vintage heating system, the temperature can drop instantly when a house or window is actually opened, and the result is that your system constantly functions electricity and fuel to pay for this heat range loss.
It would seem reasonable to assume that sun power panels would produce electricity from your sun's heat, since heat can be used in the conventional generation of electricity by your utility companies from their power factories. Second, wiring your solar power systems in parallel a configuration boosts the amperage from your solar panel technique. Another advantage regarding monocrystalline panels would it be is designed to install in your more info constraint space or room. You'll get quite possibly the most energy for your dollars when you allow professional solar power contractors to look at your building, your energy requires, and your landscape before determining one of the best position for your solar panel products and the internal design within the panels themselves. Therefore you really need to contact a few screen manufacturers to know the way they price their products prior to deciding to sign on the particular dotted line.
Sure solar cell cost can easily be outweighed in doing what is brought back to the budget economically, but they are vital for the surroundings. And don't possibly be fooled into convinced that just because solar cell installers are MCS certified there're highly experienced, as this isn't always possible. Are there ways that they you could most likely save electricity, or upgrade for you to more energy successful appliances? For example, that would turn out to be 00 divided from . 25. Would you consider looking into the situation further? You may be capable of geting them for a minimum of cost if you are going to help take all of them down and take the different used panels from the dealer's hands.
This discovery trigger the development of solar panels composed of silicon, which are consequently linked together to make a panel. If you build your own private cheap solar heating elements, keep the invoices and keep thorough records, just in case of each audit. Older solar shingles were hard to increase a roof with the way they mounted and linked with the homes electricity system. Everyone who has read about solar lights recognizes this - in any case that is why is the lights the sun's. The outer conduit remains cold in contrast to the temperature from the tube can be than 150C.
So individuals everywhere are researching to enjoy the great things about electricity at. All of the major solar cell providers, such as Silicon Solar energy, Inc and Powerfilm, have had a return the creation of panels. When selecting which configuration to apply, you need to make note of two things. These panels will often be used in secureness solar lights.
Certainly, a contractor's quotation depends on how big your place is and your own average electricity absorption. If the cell can be set up for 24 volt production, there will turn out to be 72 cells so your two 12 volt sets of 36 each are usually wired in chain, usually with a good jumper, allowing the solar power to output all day and volts. We simply really need it set up individuals home and invest in it merely within the installation. Never try out mounting home solar panels of your personal, unless you include the mandatory experience.
When a product provides results, it?s inevitable that unscrupulous individuals will seek to emulate it.
Tampa, FL (PRWEB) March 25, 2012
When a product provides results, it?s inevitable that unscrupulous individuals will seek to emulate it. Russell Bly, CEO of Liberty Health Network (LHN) reminds consumers to be vigilant in their search to obtain original Beau Visage anti-aging products and only order the firm?s Anti-aging Facial and Facelift Mask from LHN approved sources and the company?s page on Amazon.com.
?When a skeptic uses our Nonsurgical Facelift Mask and it provides noticeable results from the very fist application, skeptical turns to fanatical,? said Bly.
Demand for the firm?s products continues to grow, with sales to men up 83 percent over February of 2011. Amazon.com sales of Beau Visage products were up by 407 percent in Feb. of 2012 versus Jan. of 2012, a testament to the product line?s efficacy and popularity.
LHN?s ?As Seen On TV? products encompass a complete line of powerful anti-aging products that can be purchased over the counter without a doctor?s prescription. The firm?s proprietary formula is available in a facial cleanser, toner, cr�me and moisturizer. It works on wrinkles, sags and blemishes to reduce the outward signs of aging from every day sources that includes the sun and air-borne pollutants.
LHN?s exclusive formula offers fast results at affordable costs and works equally well for men and women. The Beau Visage Anti-aging Non-Surgical Facelift Cr�me Facial Mask helps users look five years younger with the very first application. It smooths wrinkles and lifts sagging skin for a more youthful appearance. The Non-Surgical Facelift tightens, tones and lightens blemishes without the need for expensive and dangerous surgery. It contains no salicylic or glycolic acid that can dry and damage sensitive skin.
For day or night use, the firm?s Anti-aging Face Lift Mask repairs the ravages of UV rays from the sun. The fragrance-free mask leaves no greasy residue and rejuvenates skin with antioxidants and moisturizers. The specially blended formula addresses a myriad of skin conditions, including fine lines and wrinkles, loose and sagging skin and acne prone skin, along with pigmentation problems, enlarged pores, and dry, cracked skin.
The top rated Beau Visage Facial Cleanser is mild yet effective and safe for everyday use. It?s hypo-allergenic formula is gentle on skin and fragrance free. Enhanced with rosemary, aloe, essential oils and acai extract, the cleanser provides skin with nourishment and protection. It cleans without harsh chemicals, tightens pores and provides an essential step in any beauty regimen.
For toning, closing pores, removing makeup and firming skin, Beau Visage Toner excels. Comprised of 11 herbs, moisturizers and witch hazel, it removes deep down dirt and penetrates the outer layer of skin to help hold in moisture.
The superior performance of Beau Visage products has made them a favorite worldwide. The company?s Anti-aging Facial and Facelift Mask are highly sought beauty essentials, providing consumers with an affordable solution that protects skin, while preventing and repairing the damage from every day pollutants and UV rays for a more youthful visage.
Liberty Health Network is one of the nation?s leading Direct and Internet Marketing companies with a state-of-the-art Global Distribution facility in Tampa Bay, Fl. For 12 Years, the Liberty Health Network name has been synonymous with high quality Mortechem-Free Nutritional Supplements, Anti Aging Skin Care, and Internet Web Applications. The statements made on this website have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, prevent, treat, or cure any disease.
Businesses or Individuals interested in distributing Liberty Products or requiring more information on this topic should contact Chief Operating Officer Russell Bly at (813) 774-8191 or e-mail at office(at)libertyhealthbiz(dot)com.
The new SkinMedica Vitamin C + E Complex from Skincare Market Inc. is selling for the best price nationwide guaranteed. This new product shows results in less than 3 weeks with its new innovated formula that includes both vitamin C and E.
Los Angeles, CA (PRWEB) March 22, 2012
Skincare Market Inc. has recently released a new product called the SkinMedica Vitamin C + E Complex. This regenerated product is a scentless formula that consists of over 15 percent stabilized vitamin C with vitamin E that rejuvenates the skin to prevent aging and damage. This combination of vitamins enables the skin to maintain flawless antioxidant protection, withholding any signs of dryness or UV damage. The collaboration of these invigorating vitamins prevent any types of blemishes.
Aside from blemish prevention, the SkinMedica Vitamin C + E Complex soothes and cleans the skin, leaving it moisturized and smooth. With its ability to fight aging, this formula boosts collagen production, which helps the skin look perfect. This advanced skin care product allows cells to be renewed faster than ever, and heals damage while protecting it from any future breakouts. For the best results, apply a single pump to the face and neck only in the morning.
The face of Maybelline for years, the model, 33, has also dabbled in acting, appearing in Van Helsing, and reality TV, where she took a spin on Dancing with the Stars.
In 2007, Maran established Josie Maran Cosmetics, her own natural product line. Since the launch, the Argan oil-based skincare and cosmetics have been the recipient of various industry awards.
This is a perfect time to start writing to you, dear PEOPLE peeps. You?re catching me at a huge moment in my life. My daughter Rumi Joon is growing almost as fast as Josie Maran Cosmetics (JMC), the business I started when I was pregnant with her.
The eco-movement is growing as people all over catch on to the need to protect our precious planet, which makes the future look really bright ? and makes me really happy.
And my belly is growing, too! In July, my husband, Ali, our daughter and I will welcome our second child into this beautiful world.
I bet I know what you want to ask me: Is it a boy or a girl? Well, we love to be surprised. And I really can?t imagine a better surprise than meeting this little person who?s going to be at the center of our lives forever! We?re looking forward to welcoming our new little munchkin.
Here?s an intro to my lovely little family:
ME: Born and raised in Northern California, I love to have a good time, go on adventures, invent new ways of doing things, cook, go to new restaurants, play frisbee, learn, ask questions, give, have picnics on the beach with my husband and daughter and create healthy amazing cosmetics to share with the world.
ALI: My husband, my best friend, my business partner and the best papa in the world! We met in 2004 at a Cirque du Soleil party and it was love at first sight. He teaches me so much and loves me perfectly every day. I can?t wait to see him tickle two kids at once.
RUMI JOON: Our 5�-year-old daughter. She is the most curious, happy person I know. No sitting back in life, just full of courage to take on the world. She loves to play in the dirt and collect rocks and crystals, but she is also a girly-girl who likes to do my friend?s makeup.
Rumi?s totally excited about being a big sister. She?s hoping for a little brother. I?m just happy I get an eager little helper.
It?s so touching to me when she puts her head on my belly and talks to the baby. The cutest thing is when she blows on my bump to make funny noises so the baby laughs.
There?s so much to appreciate about my life every single day, and I make a big point of taking time to smell the roses and noticing how lucky I am. I never want to take that for granted.
Rumi Joon loves the bump ? Courtesy Josie Maran
Expecting for the second time reminds me of my fun ?start up JMC? experiences during pregnancy number one. I spent the whole time belly-deep in makeup and packaging samples and shipping boxes, making big decisions while I was under the influence of all those crazy hormones.
Luckily, my husband is my business partner as well as my life partner, so I never had to do the heavy lifting alone, literally or figuratively. Throughout this pregnancy, too, Ali and I are making decisions and doing things together ? whether it?s finding the best kindergarten for Rumi Joon, dreaming up new and exciting expansion plans for JMC, or planning our family?s relocation to Pennsylvania for the summer.
In the Maran-Alborzi household, it?s all for one, and one for all.
Speaking of ?all? ? stay tuned for updates on my growing belly and my growing family. I?ll be checking in as things develop ? right up to and beyond the birth of baby number two.
I look forward to sharing this whole miraculous motherhood adventure with you!
It's officially spring and who doesn't want to start the season off looking and feeling fresh? That's why our Deals and Steals segment is all about beauty with exclusive discounts on everything you need for your own personal makeover.
Today's installment has great deals, only for "Good Morning America" viewers, on must-have beauty products from a hair removal laser kit, anti-wrinkle light therapy, airbrush foundation and bronzer, cosmetics and more. Plus, you'll get free shipping on every item!
First, the fine print:
1. Use the promo codes and links provided below only on the dates listed to receive the savings.
2. All deals available only while supplies last. No back orders or rain checks unless specified by the retailer.
3. Exclusive deals are applicable only to the items specified below. The savings are not applicable to other items on each site.
4. Deals cannot be combined with other coupons and offers.
5. Contact retailers directly for any questions about products, pricing and delivery before ordering online.
6. You might experience temporary technical issues because of the high volume of traffic. Thanks for your patience.
To suggest an exclusive deal for my consideration, connect with me directly at Facebook.com/Tory. If you have any trouble accessing a deal, you're welcome to email me directly through sparkandhustle.com/tv. I will answer you the same day.
'GMA' Deals and Steals: Jewelry, Hoodies, Watches Watch Video
Valentine's Day Secret Deals and Steals Watch Video
'GMA' Deals and Steals: Products by Moms For Moms Watch Video
The TRIA laser is the first and only FDA-cleared at-home laser available for safe and effective hair removal that delivers permanent results. In as little as two treatments, you may begin to see results, and in as little as six months, you could be free from unwanted hair forever. The TRIA Laser's easy-to-use digital display and five comfort settings allow for a truly smooth experience. In the current issue of In Style, Kim Kardashian calls the TRIA one of her top must-haves: "I use this at-home laser to touch up my legs and arms when I don't' have time to go in for an appointment." This exclusive deal includes the device, plus two products in a travel bag. Free shipping!
Cut dry time up to half with this salon professional blow dryer, which the company says is a favorite of Jennifer Aniston and Ellen DeGeneres, among others. It's equipped with 2000 watts of power, an ionic charger, cool shot release button and multiple heat and speed settings. Various styles available in red, black and white. Limit one per customer. Free shipping!
The GO SMiLE Power Whitening Light is an at-home, light-accelerated teeth-whitening system that's clinically proven to whiten teeth up to seven shades with one treatment in less than 45 minutes. In addition to the Smile Whitening Light, the set contains two powerful gel-like formulas (Pre-Whitening Gel and Smile Whitening Ampoules) that are layered onto teeth to accelerate the whitening action for fast results. The box contains three treatments ? share with the family or do it yourself once a week or as desired. Free shipping!
A favorite of beauty editors and dermatologists?now available for home use, LightStim is an FDA-cleared LED light therapy device that increases collagen and boosts elastin production by emitting a soothing, gentle, relaxing warmth that users love. LightStim for Wrinkles is clinically proven to reduce fine lines and wrinkles, creating more youthful looking skin for ages 25 and up. The majority of users keep the device plugged in near a couch or bed to treat areas while watching TV?holding the light in place for two to three minutes per desired location. Limit two per person. Free shipping!
The new SkinMedica Vitamin C + E Complex from Skincare Market Inc. is selling for the best price nationwide guaranteed. This new product shows results in less than 3 weeks with its new innovated formula that includes both vitamin C and E.
Los Angeles, CA (PRWEB) March 22, 2012
Skincare Market Inc. has recently released a new product called the SkinMedica Vitamin C + E Complex. This regenerated product is a scentless formula that consists of over 15 percent stabilized vitamin C with vitamin E that rejuvenates the skin to prevent aging and damage. This combination of vitamins enables the skin to maintain flawless antioxidant protection, withholding any signs of dryness or UV damage. The collaboration of these invigorating vitamins prevent any types of blemishes.
Aside from blemish prevention, the SkinMedica Vitamin C + E Complex soothes and cleans the skin, leaving it moisturized and smooth. With its ability to fight aging, this formula boosts collagen production, which helps the skin look perfect. This advanced skin care product allows cells to be renewed faster than ever, and heals damage while protecting it from any future breakouts. For the best results, apply a single pump to the face and neck only in the morning.
Kim Marinetto, RN, master aesthetician and co-owner at AVIE! MedSpa and Laser Center in Leesburg, VA, announces Exercise Your Skin?, a new approach to skin rejuvenation.
Leesburg, VA (PRWEB) March 21, 2012
Kim Marinetto, RN, master aesthetician and co-owner at AVIE! MedSpa and Laser Center in Leesburg, VA introduces Exercise Your Skin, a multi-dimensional program designed to change the way you think about your skin and skincare. Dr. Betsy Vasquez, AVIE!?s Medical Director, states, ?The Exercise Your Skin program at AVIE! takes a simple concept and gives you great results. Your skin is the largest organ in your body, and like your muscles it needs exercise and care to stay healthy and vibrant. Just as you would not go to the gym once and expect dramatic results, regular exercise is imperative to your skin?s health and overall appearance.?
The Exercise Your Skin program at AVIE! is a comprehensive approach which includes several layers of treatment, including a professional skin analysis, personalized consultation, before and after photos, one-on-one education, a customized plan and phone support. The highly-skilled skin care experts at AVIE! guide each client through a personalized regime to achieve vibrant, healthy-looking skin. Treatments may include regular photo facials, chemical or laser peels, Botox, injectable fillers, skin tightening or specific home care that will revitalize and nurture the skin.
Kim Marinetto explains, ?The solutions for aging skin are correction, maintenance and prevention. Medical spa skin care and laser treatments stimulate the fibroblasts in the skin which allow the skin to generate new collagen. Skin is able to repair and rebuild itself.? Kim continues, ?The skin is the largest organ of the human body and when properly stimulated it will respond to a regular regime of exercise just like our muscles do. We customize each program for the individual according to the goals they would like to reach. We are similar to personal trainers in that way.?
For more information about ?Exercising Your Skin? and to schedule a complimentary consultation at AVIE!, call (703) 737-0197 or email info (at) aviemedspa (dot) com.
About AVIE! Medspa & Laser Center AVIE! Medspa & Laser Center offers the latest in cosmetic medical spa treatments in a relaxing spa environment in Leesburg, VA. Spa Director and Owner, Kim Marinetto, RN and Master Aesthetician, in conjunction with Medical Director and Co-owner, Betsy Vasquez, MD, FACS and their highly skilled team provide specialized medspa programs so each of their client's needs are addressed on an individual basis with personalized follow-ups. Their treatments have minimal to no downtime. Services include: ProLipo? Laser Liposuction, Botox�, Juvederm�, Microdermabrasion, Chemical Peels, Micro Laser Peels, Photo Facials, Skin Tightening, Pro Fractional Skin Resurfacing, Laser Hair Removal, Clinical Facials with Professional Skin Analysis and Medically Supervised Weight Loss. AVIE! also carries physician level skin care and make-up, as well as offering gift certificates for special occasions. Consultations are complimentary, and financing is available. For more information please call 703-737-0197 or visit http://www.aviemedspa.com.
About Kim Marinetto, RN & Master Aesthetician Kim Marinetto has over 20 years of experience as a Registered Nurse, and in the past 5 years has focused her practice on cosmetic medicine, adding to her credentials a Medical Aesthetician Certification in 2006, along with additional certifications in Botox Cosmetic, Facial Fillers, Sclerotherapy and various advanced laser systems. Kim is a certified Master Aesthetician and is licensed with the state of Virginia. Additionally, Kim has done extensive training on laser technology and her coursework is recognized by the AMA.
About Betsy Vasquez, MD Dr. Vasquez graduated cum laude from Princeton University in New Jersey and received her medical degree from Albert Einstein College of Medicine in New York in 1986. She completed her residency in Otolaryngology-Head and Neck Surgery at Georgetown University in Washington, DC in 1992.
Antioxidants Used as Anti-Aging Treatment May Also Kill Cancer Cells; Be Better Than Chemo
Antioxidants "are potentially better chemotherapeutic agents than ones currently used", the researchers say
KJ Myung, Senior Investigator, Genetics and Molecular Biology Branch, Division of Intramural Research, NHGRI. Photo by Maggie Bartlett , NHGRI
Three antioxidants - resveratrol, genistein and baicalein - are used or studied as anti-aging treatments and to treat heart disease, type 2 diabetes, osteopenia and osteoporosis and chronic hepatitis; resveratrol found in red wine is in 44 clinical trials as potential treatment for even Alzheimer?s disease
By Larry Thompson Chief, NHGRI Communications and Public Liaison Branch
March 20, 2012 - Antioxidants have long been thought to have anti-aging properties, primarily by protecting a person's genetic material from damaging chemicals. The story, however, now appears to be much more complicated.
National Institutes of Health researchers from two institutes and one center have demonstrated that some antioxidants damage DNA and kill cells instead of protecting them. The findings, published in the Proceedings of the National Academy of Sciences on March 19, 2012, also suggest that this surprising capability may be good for treating cancer, but may prove cautionary when using antioxidant-based medicines to treat other disorders, such as diabetes.
"It's an unexpected discovery," says Kyungjae Myung, Ph.D., a senior investigator in the Genetics and Molecular Biology Branch of the National Human Genome Research Institute (NHGRI), and the senior author on the report. "It may have important clinical applications in treating people with cancer, especially if they have failed previous treatments."
Drinking more than four cups of coffee daily cut risk by 25%; coffee fast-emerging as protective against a number of diseases- see video - Nov. 28, 2011
Study important because it suggests that resveratrol and caloric restriction may govern the same master genetic pathways related to aging - June 4, 2008
Many people attempt to boost their levels of antioxidants by eating fruits and vegetables, nuts and grains, or by taking vitamins such as A, C, E and beta-carotene, among others. Some research suggests that antioxidants soak up compounds called free radicals produced by burning oxygen during normal respiration. Free radicals cause random chemical reactions that can damage cellular components, including DNA, leading to disease. By adding antioxidants to the diet, many people hope to slow down the process that some believe contributes to the normal process of aging.
Dr. Myung did not set out to challenge this anti-aging strategy, and the new findings may not fundamentally alter the approach; much more study will be needed. Instead, his lab studies DNA repair, the enzyme systems within a cell that fix mistakes and other damage that routinely accumulate in DNA as cells simply live and divide to make daughter cells. Researchers know that naturally occurring defects in DNA repair can lead to a number of disorders, including cancer.
To study DNA repair, Dr. Myung's group sought a new way to easily identify chemicals that damage DNA and then use those chemicals to study cellular repair mechanisms, a basic research question. Using a laboratory grown cell line from human kidneys, the NHGRI team, which included Jennifer Fox, Ph.D., lead author and post-doctoral fellow, developed a novel laboratory test, or assay, that readily shows when a chemical exposure damages DNA.
With the test developed, Dr. Myung's team formed collaborations with two other NIH research groups: The first was with what is now the NIH National Center for Advancing Translational Science (NCATS). Over the last several years, a team led by Christopher Austin, M.D., head of the NCATS laboratories, has developed high-throughput chemical screening systems using robotics. Dr. Austin agreed to use Dr. Myung's assay to rapidly test thousands of chemicals for their ability to damage DNA. But what chemicals should they test?
In 2008, the NIH Chemical Genomics Center, then part of NHGRI and now at NCATS, the National Institute of Environmental Health Sciences (NIEHS) and the U.S. Environmental Protection Agency (EPA) formed an initiative called Tox21 to develop high-throughput screening tests that measure cellular harm caused by environmental chemicals. The Tox21 team created a library of some 2,000 compounds and agreed to test them against Dr. Myung's assay. The NHGRI researchers also added a commercially available chemical collection to the screening runs for a total of some 4,000 chemicals.
The screening runs produced surprises, identifying 22 antioxidants that damaged DNA. Three of the antioxidants - resveratrol, genistein and baicalein - are currently used ? or being studied ? to treat several disorders, including heart disease, type 2 diabetes, osteopenia and osteoporosis and chronic hepatitis, as well as serving as an anti-aging treatment.
Not only did the antioxidants damage the DNA, the researchers found, but also, in dividing cells (such as in tumors), the antioxidants can be lethal, killing the disease-causing cells.
"This is what's cool about biology," Dr. Austin said. "Just when we think we understand something, it turns out to be more complex than we thought. Not only did the NHGRI team produce a novel way to measure DNA damage, but their test has given us insights into the effects of chemical compounds that were not seen in more conventional strategies."
The discovery opens up several new lines of research. As a first step, the collaborators are dramatically expanding the number of compounds ? more than 300,000 ? that will be tested with the new assay. The Tox21 team also has decided to include the NHGRI test in its standard screen for biological harm produced by environmental chemicals.
The clinical implications for these findings are more complicated. This initial discovery is only in lab-grown cell lines, not even in intact organisms. The relevance for humans has yet to be demonstrated.
Still, there is plenty of work already underway. Other researcher teams had launched various studies of these DNA-damaging antioxidants in various diseases. For example, 44 studies are currently listed in www.clinicaltrials.gov for resveratrol, which is found in many foods, including red grapes and wine, peanuts and chocolate. The studies focus on treating Alzheimer's disease, type 2 diabetes, obesity, inflammation, colon cancer, multiple myeloma, and testing other anti-aging strategies, among others. The newly reported study does not suggest that resveratrol in red wine is harmful; the dose is probably too low to be significant, Dr. Myung said.
Researchers also have launched 43 studies on genistein, including trials to treat cancers of the prostate, pancreas, bladder, breast, kidney and skin (metastatic melanoma) and as adjunct treatments for rare diseases such as cystic fibrosis.
Even though the antioxidants damaged the DNA, the researchers reported that the chemicals did not cause genetic mutations, another surprise. "Because they don't cause genetic mutations, antioxidants may be useful for treating cancer," Dr. Myung said. "Standard chemotherapy mutates the tumor's DNA, speeding its evolution and sometimes allowing it to escape the toxic treatment intended to kill it. This leads to multi-drug resistance in some cancer patient's disease."
To test whether the antioxidants might help, the NHGRI team borrowed some multi-drug resistant cancer cells from Dr. Michael Gottesman, a National Cancer Institute researcher and NIH Deputy Director for Intramural Research. Although these cells are very resistant to anti-cancer drugs, treatment with resveratrol appeared to sensitize the cancer cells, leading to their death. "Resveratrol," Dr. Myung said, "could prove useful in treating multi-drug resistant cancers."
The findings do raise concerns about using antioxidants to treat disorders, as treatment with high doses may cause unexpected DNA damage that leads to other problems. "Clearly," Dr. Myung said, "much more study will be needed."
>> To read updates to this story or post comments ? click here.
>> Read the complete research report on the study published in the Proceedings of the National Academy of Sciences ? click here.
A cosmetics shop in Nantong, Jiangsu province. The traditional cosmetics market is ushering in new cosmeceutical products as investors, including pharmaceutical companies, eye the profitable niche market. Xu Congjun / for China Daily
Although Yu Jing, 28, is a sales person for Xiuzheng Pharmaceutical Group Co, the places she mostly visits are not hospitals or pharmacies but department stores, shopping centers and supermarkets.
"I really like the job, which provides beauty products for women," said Yu, who looks young and energetic with smooth, fresh-looking skin. "What I am selling is cosmeceuticals, the most popular type of skin improvement products for women pursuing a 'green' lifestyle and fashionable ladies."
Cosmeceuticals - the combination of cosmetics and pharmaceuticals - are cosmetic products with biologically active ingredients purporting to have medical or drug-like benefits.
The boom in cosmeceuticals coincides with people's ever-increasing interest in natural and safe products, according to Yan Shixiang, deputy-director of the Beauty and Cosmetics Committee under the All-China Federation of Industry and Commerce.
According to the National Bureau of Statistics, retail sales of consumer goods in China increased by 21.6 percent year-on-year in 2010, while the figure for the cosmetics sector was 22.1 percent. Yan's committee predicted that sales of cosmetics in China will reach 120 billion yuan ($19 billion) in 2012. It also said that the annual growth of cosmeceuticals expenditure in the nation will be higher than that of the cosmetics industry in general and will stay in double digits over the coming decade.
Xiuzheng Pharmaceutical Group is one of the top 10 drugmakers in China with sales hitting 60 billion yuan last year. It started producing cosmeceutical products in 2007, the raw materials of which are mainly derived from plants.
According to Sun Zhenwen, general manager of the Jilin-based company, the annual sales growth of Xiuzheng's cosmeceuticals was more than 300 percent. "We will continue to invest in this business (cosmeceuticals). A research and development project, supported by funds of more than 1 million yuan, was launched last year," said Sun.
Xiuzheng's case is not unique: Many pharmaceutical companies in China are expanding their businesses into the cosmeceuticals sector.
Yunnan Baiyao Group Co Ltd acquired three local companies for 63 million yuan in 2010. One of them - Jindian Pharmaceutical Co Ltd - has been engaged in skin improvement drugs and cosmetics development and manufacturing since 1989. Yunnan Baiyao helped Jindian to improve its technology and equipment and made it the group's cosmeceuticals branch.
In 2004, Beijing Tongrentang Group Co Ltd set up a subsidiary - Beijing Tongrentang WM Dianorm Biotech Co Ltd - to specifically develop and promote cosmeceutical products. The sales revenue of Tongrentang, which was set as long ago as 1669, amounted to 2.94 billion yuan in 2010, of which 20 million yuan came from the cosmeceuticals unit.
Mei Qun, general manager of the Beijing-based traditional Chinese medicine producer, said the cosmeceuticals business is the key focus of the company in the 2011-2015 period. Tongrentang is to develop 300 new products during this period, one-third of which will be cosmeceuticals.
However, Chinese cosmeceuticals cannot compete with some foreign brands, such as Vichy and Avene, in the domestic market. Li Shuhua, an analyst with Orient Securities Co Ltd, attributed this inability to the lack of a sound distribution network and poor knowledge of techniques to promote cosmetics.
Tongrentang has been trying to sell its cosmeceuticals in its own chain of pharmacies but few customers have noticed them. It also tried to sell its products to professional beauty salons, but failed. Now it's entering department stores and supermarkets to attract people's attention.
Li suggested the companies should take specific cosmetic retailing chains, such as France-based Sefhora, Watsons and Mannings, to sell their products. "Young Chinese citizens, who are major consumers of cosmetics, prefer to purchase cosmetics and healthcare products in these professional chains," she said.
Beijing resident Feng Ruobing has seen Tongrentang cosmeceuticals in a big department store. "It was a small counter that was selling Tongrentang skin improvement and hair maintenance products. I believe the brand is reliable and want to buy it," said Feng, 35, an administration officer in a multinational company. "However, the assistant could not provide good answers to my questions on the functions and ingredients of these products; so I gave up."
Xiuzheng's Yu said her company has trained a group of beauty assistants. "When women choose cosmetics, they want first to have a try and get clear and thorough knowledge about them. That's where our beauty assistants can help," said Yu.
"But cosmeceuticals are still a kind of cosmetic. They are not pharmaceutical products so people should think clearly what they really want and not have very high expectations of the efficiency of these products," she said.
We live in a fast paced world and as such, even learning how to get rid of acne should be a very quick and simple process. No one has time to labor over anything for too long anymore and I think treating acne should be no different. That is why I have taken the time to research this very important matter. Acne is a very common skin related ailment that affects most if not all of us at some point in our lives. Acne often occurs when we are stressed or when we are not taking the time to monitor our diets carefully. So a quick and easy way to get rid of acne, is to eat right. Eating more fresh fruits and vegetables is the first place to start. That is because eating more of these kinds of foods will ensure that you do not eat too many of the fried foods that are notorious for making acne worse. Once your diet is in tact, exercise is the next step. This will ensure that your pores do not become clogged, since exercise makes you sweat a lot more.
This entry was posted on Thursday, March 15th, 2012 at 11:14 am and is filed under Beauty. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.
